Sean Lamont, the Northampton winger, will not feature in Scotland's remaining autumn internationals after a scan confirmed that he suffered a hamstring injury against New Zealand at Murrayfield on Saturday.
Lamont pulled up abruptly during an unsuccessful attempt to prevent Richard Kahui, the New Zealand centre, from scoring the third try in the All Blacks' 32-6 victory.
James Robson, the Scotland team doctor, said: "A scan has shown a small amount of damage to Sean's hamstring, enough to rule him out of the remainder of the autumn tests."
Wales will likewise name an altered line-up for their next match after their head coach, Warren Gatland, made 12 changes for the Millennium Stadium clash against Canada on Friday night. Skipper Ryan Jones, wing Leigh Halfpenny and centre Tom Shanklin are the only three players retained following Saturday's 20-15 loss to world champions South Africa.
Cardiff Blues prop John Yapp received a surprise call-up from outside the squad and will replace Duncan Jones, the injured Ospreys loosehead. Yapp's Blues colleague, wing Tom James, could also be summoned by Gatland if full-back Morgan Stoddart fails a fitness test. Should Stoddart be ruled unfit, Halfpenny is set to replace him at full-back, with James starting on the wing.
An ongoing achilles problem has ruled out centre Gavin Henson, while Jones moves from blindside flanker to No8 in place of Andy Powell. The flanker positions will be taken by Dafydd Jones and Robin Sowden-Taylor.
It is all change in the front five, where Luke Charteris, the towering Newport Gwent Dragons lock, is likely to make a rare start. The Scarlets wing, Mark Jones, returns following a knee injury.
Elsewhere, James Hook wears the No10 shirt, with two uncapped players named on the bench in Sale Sharks prop Eifion Roberts and Ospreys fly-half Dan Biggar.
There is a full Test debut for Scarlets No9 Martin Roberts, with Sale's Dwayne Peel among the replacements.
"We have a short turnaround before we face Canada, and this was always going to be a game in which we tried to utilise our squad," said Gatland.
"We have a chance to put defeat against South Africa behind us and really try to build some momentum before New Zealand and Australia come to town, so we know what we need to achieve against Canada. There are lots of changes from the weekend, but we have maintained consistency by keeping Ryan in there as captain, and we have some experience and impact players, too, on the bench."
