Arsenal v Manchester City (Saturday, 3pm)
Arsenal welcome back Cesc Fábregas after three months out with medial knee ligament injury, but the Gunners will have to make do without leading scorer Robin van Persie, who injured his groin while playing for Holland against Scotland last Saturday, and Eduardo who suffered a similar problem while playing for Croatia.
Midfielder Abou Diaby (thigh) is out while Samir Nasri (virus) and Carlos Vela, who has had to make a long journey back from Mexico duty, are also doubtful.
However, Theo Walcott and Emmanuel Adebayor return as does Nicklas Bendtner (knee).
Arsenal (from): Almunia, Sagna, Toure, Gallas, Clichy, Walcott, Denilson, Fábregas, Arshavin, Bendtner, Adebayor, Fabianski, Djourou, Gibbs, Vela, Eboue, Silvestre, Song, Nasri.
Manchester City manager Mark Hughes could be without striker Craig Bellamy but expects top-scorer Robinho to be fit for selection against Arsenal.
Bellamy is a major doubt with the knee injury that flared up again on international duty with Wales and forced him to miss his country's midweek defeat to Germany.
Robinho also limped off during Brazil's 3-0 win over Peru on Wednesday, but Hughes is hopeful the 24-year-old will be available as City try and claim a first away league win since August.
Wayne Bridge could return from a hamstring strain, while Michael Johnson, Martin Petrov, Daniel Sturridge, Benjani and Didi Hamann are all nearing return from injury.
Manchester City (from): Given, Richards, Onuoha, Dunne, Zabaleta, Wright-Phillips, Elano, De Jong, Kompany, Robinho, Bojinov, Bridge, Garrido, Fernandes, Evans, Etuhu, Berti, Vassell, McGivern, Hart.
Blackburn v Tottenham (Saturday, 12.45pm)
Blackburn striker Roque Santa Cruz is to see a specialist next week if he fails to show signs of a recovery from a knee tendon injury.
The Paraguay international has been out for a month and misses a fifth successive game tomorrow when Tottenham visit Ewood Park for an early afternoon clash in the Premier League.
It is the same situation with midfielder David Dunn, who has been out of action for three weeks with an achilles problem.
Midfielder Vince Grella has returned to training following a groin injury and, although in the squad, tomorrow's game probably comes too soon for him to figure.
Allardyce's injury list stretches to four key players, with Brett Emerton and Steven Reid on the long-term casualty list.
Blackburn (from): Robinson, Bunn, Ooijer, Khizanishvili, Nelsen, Samba, Simpson, Warnock, Givet, Olsson, Villanueva, Tugay, Andrews, Diouf, Treacy, Mokoena, McCarthy, Roberts, Pedersen, Grella.
Tottenham club captain Ledley King should be fit for the trip to Ewood Park after resting his suspect knee during the international break.
Alan Hutton returned for Scotland from his foot injury last week but Jermain Defoe is still out, also with a foot complaint, although he is running again.
Spurs boss Harry Redknapp will make late checks on players who have been on international duty such as Wilson Palacios, Luka Modric and Darren Bent – who hobbled out of England training this week.
Tottenham (from): Gomes, Cudicini, Corluka, Hutton, Chimbonda, Bale, Assou-Ekotto, King, Woodgate, Dawson, Modric, Jenas, Zokora, Lennon, Huddlestone, Palacios, O'Hara, Bentley, Pavlyuchenko, Campbell, Keane, Bent.
Everton v Wigan (Sunday, 3pm)
Everton manager David Moyes will make a late decision on the fitness of Tim Cahill for Sunday's visit of Wigan as the midfielder has not yet returned from international duty.
The Australian has spent the last week in Sydney recovering from a calf injury but did not play any part in the Socceroos' 2-0 win over Uzbekistan on Wednesday.
Moyes is also waiting for the return of American goalkeeper Tim Howard, the only other player yet to make it back after the internationals.
Right-back Tony Hibbert has resumed training after a thigh problem but may not be ready to play against the Latics.
Everton (from): Howard, Neville, Jagielka, Lescott, Baines, Pienaar, Osman, Cahill, Fellaini, Saha, Jo, Rodwell, Baxter, Nash, Castillo, Jacobsen, Gosling, Wallace, Van der Meyde.
Wigan will be without Amr Zaki after the Egyptian striker again failed to return from international duty on time. It is the fourth time this season Zaki has gone walkabout after an Egypt game and looks set to be heavily fined by Steve Bruce as a result.
Jason Koumas has a hip problem which needs to be assessed, otherwise the Latics squad is at full strength.
Wigan (from): Kirkland, Melchiot, Bramble, Boyce, Figueroa, Watson, Brown, Scharner, Kapo, N'Zogbia, De Ridder, Rodallega, Mido, Kingson, Pollitt, Edman, Cho.
Bolton v Middlesbrough (Saturday, 3pm)
Bolton's players all returned unscathed from international duty leaving midfielders Mark Davies and Joey O'Brien (both knee) the only absentees. Defender Andy O'Brien could feature after being rested in their last game.
Bolton (from): Jaaskelainen, Steinsson, Cahill, Andy O'Brien, Samuel, Riga, Taylor, McCann, Muamba, Gardner, Kevin Davies, Elmander, Al Habsi, Hunt, Puygrenier, Makukula, Shittu.
Middlesbrough winger Adam Johnson faces a fitness test after picking up two knocks playing for England's Under-21s. Meanwhile, Chris Riggott returns from injury, midfielder Matthew Bates is back from suspension, but Robert Huth is a doubt with a sore knee.
Middlesbrough (from): Jones, Turnbull, Hoyte, McMahon, Taylor, Grounds, Huth, Pogatetz, Wheater, Riggott, Aliadiere, O'Neil, Johnson, Bates, Walker, Shawky, Downing, Emnes, Alves, Tuncay, King.
Fulham v Liverpool (Saturday, 5.15pm)
Mark Schwarzer and Clint Dempsey will play for Fulham in tomorrow's clash with Liverpool. Australia goalkeeper Schwarzer and USA winger Dempsey only returned from international duty this morning but have already been involved in training.
Fulham (from): Schwarzer, Pantsil, Stoor, Hughes, Hangeland, Konchesky, Baird, Davies, Etuhu, Dacourt, Murphy, Gera, Dempsey, Johnson, Zamora, Zuberbuhler, Kallio, Nevland, Kamara, Gray, Barnes.
Liverpool are likely to be without defender Sami Hyypia and midfielder Yossi Benayoun for the trip to Fulham.
Hyypia returned from international duty with a knee injury, and manager Rafael Benítez doubts that the centre-back will be fit for the evening kick-off at Craven Cottage. He could be fit for Wednesday's Champions League clash with Chelsea, however.
Benayoun went on World Cup qualifying duty with Israel already with a hamstring injury and now also has a calf problem.
Liverpool (from): Reina, Arbeloa, Agger, Carragher, Skrtel, Aurelio, Dossena, Babel, Mascherano, Gerrard, Alonso, Lucas, Torres, Kuyt, Ngog, Insua, Cavalieri, Riera.
Hull v Portsmouth (Saturday, 3pm)
Striker Daniel Cousin is Hull's only doubt for tomorrow's visit of Portsmouth. Cousin has missed the last two games with a back complaint and, having not reported for international duty with Gabon, must still prove his fitness.
The club's other injury concerns, Michael Turner (thigh), Kamil Zayatte (knee), Andy Dawson (thigh) and captain Ian Ashbee (hamstring), are all fit.
George Boateng (knee) is set to return to full training next week but Anthony Gardner (back) and Jimmy Bullard (knee) are out for the season.
Hull (from): Duke, Ricketts, Turner, Zayatte, Dawson, Mendy, Ashbee, Marney, Kilbane, Geovanni, Manucho, Garcia, Barmby, Fagan, Halmosi, Folan, Doyle, Hughes, France, Cousin, Myhill.
Peter Crouch, David James and Glen Johnson have all returned unscathed from England duty for Portsmouth's clash at Hull and Niko Kranjcar has reported no ill-effects after his efforts for Croatia.
On-loan Liverpool winger Jermaine Pennant has recovered from a thigh injury and should return to the attack, enabling Johnson to revert to his more familiar full-back role but Armand Traore's hopes of a first-team recall have been hit by a damaged ankle playing for France Under-21s.
Reserve goalkeeper Jamie Ashdown is back after three months out with an ankle ligament injury and could return as cover for James on the substitutes' bench but Jerome Thomas and Marc Wilson picked up further knocks in their midweek comeback attempts for the reserves.
Portsmouth (from): James, Johnson, Campbell, Distin, Hreidarsson, Pennant, Mullins, Davis, Nugent, Kranjcar, Crouch, Kanu, Kaboul, Pamarot, Utaka, Hughes, Belhadj, Basinas, Ashdown, Begovic.
Manchester United v Aston Villa (Sunday, 4pm)
Gary Neville is expected to return for the first time since January as Manchester United look to halt a two-game losing sequence against Aston Villa at Old Trafford.
Neville has been struggling to overcome a groin injury but came through a reserve team outing on Monday without a problem and is set to figure for Sir Alex Ferguson's side.
Wayne Rooney, Paul Scholes and Nemanja Vidic are all suspended, Dimitar Berbatov (ankle) is out for a fortnight and Anderson is not likely to play after picking up a knee injury on World Cup duty with Brazil.
Manchester United (from): Van der Sar, Foster, Kuszczak, Neville, O'Shea, Ferdinand, Evans, Evra, Fabio, Ronaldo, Nani, Fletcher, Gibson, Possebon, Carrick, Park, Giggs, Tevez, Welbeck.
Gabriel Agbonlahor could be restored to the Aston Villa line-up as they look to end a run of eight games without a win in all competitions against Manchester United.
Agbonlahor was left out of the starting XI for the 5-0 mauling by Liverpool at Anfield before the international break with John Carew and Emile Heskey preferred in attack. But Heskey is ruled out with a hamstring injury he suffered after scoring the opening goal in England's 4-0 win over Slovakia at Wembley last weekend.
O'Neill has to decide whether left-back Wilfred Bouma is ready to play any part after eight months out with a dislocated ankle. He came through a third reserve game in mid-week with no ill effects.
Aston Villa (from): Friedel, Guzan, Reo-Coker, L. Young, Knight, Cuellar, Davies, Shorey, Bouma, Milner, Gardner, Petrov, Barry, Sidwell, Salifou, A. Young, Agbonlahor, Carew, Delfouneso, Heskey.
Newcastle v Chelsea (Saturday, 3pm)
Newcastle manager Alan Shearer hopes to have three key players available for his first game in charge against Chelsea tomorrow.
Steven Taylor (ankle) and Sebastien Bassong (groin) are improving and have not yet been ruled out, while Damien Duff (hamstring) was expected to train today. Danny Guthrie is back in contention after an eight-match lay-off with a torn hamstring and strikers Andy Carroll (ankle) and Xisco (fractured toe) have returned to training.
But Shola Ameobi is out with an ankle problem and Joey Barton (fractured metatarsal), Mark Viduka and Ignacio Gonzalez (both achilles) remain on the sidelines.
Newcastle (from): Kirkland, Melchiot, Bramble, Boyce, Figueroa, Watson, Brown, Scharner, Kapo, N'Zogbia, De Ridder, Rodallega, Mido, Kingson, Pollitt, Edman, Cho.: Harper, Forster, Krul, S Taylor, Beye, Bassong, Coloccini, Enrique, Edgar, Cacapa, Butt, Duff, R Taylor, Gutierrez, Nolan, Guthrie, Lovenkrands, Geremi, Smith, Martins, Owen, Carroll, Xisco.
Chelsea are without striker Didier Drogba and right-back Jose Bosingwa for the trip to Newcastle. Drogba jarred his ankle in a training ground accident while Bosingwa returned from international duty with Portugal suffering from a hamstring strain.
Chelsea are boosted by the return of fit-again Nicolas Anelka. The France international has shaken off his toe problem to be included in the squad.
Chelsea (from): Cech, Hilario, Taylor, Belletti, Alex, Ivanovic, Terry, Mancienne, A Cole, Lampard, Ballack, Deco, Obi, Kalou, Essien, Malouda, Di Santo, Anelka, Quaresma, Stoch.
West Brom v Stoke (Saturday, 3pm)
West Brom defender Abdoulaye Meite returns to the squad for tomorrow's clash against Stoke.
Meite has recovered from a hamstring problem and illness, although he may have to be content with a place on the bench as manager Tony Mowbray is set to continue with Jonas Olsson and Shelton Martis at the centre of defence. Albion have only conceded one goal in the two games they have played together.
Mowbray looks set to retain the side that started West Brom's last match – the 1-1 draw against Bolton.
West Brom (from): Carson, Kiely, Zuiverloon, Hoefkens, Olsson, Martis, Donk, Pele, Meite, Robinson, Cech, Koren, Teixeira, Do-Heon, Valero, Brunt, Simpson, Fortune, Bednar, Moore, Menseguez.
Stoke manager Tony Pulis will assess the fitness of his international quartet ahead of tomorrow's visit to West Brom.
Republic of Ireland duo Glenn Whelan and Stephen Kelly, Senegal star Abdoulaye Faye and Denmark goalkeeper Thomas Sorensen were all due to return to training this morning.
Kelly is likely to be on standby for full-back Andy Wilkinson (back), while Pulis has jet-lag fears over Faye who played in a friendly fixture in Iran.
Amdy Faye will be recalled in central midfield if Salif Diao (groin) fails a fitness test, but striker Mamady Sidibe will play no further part this season after a damaged cruciate ligament was confirmed.
Stoke (from): Sorensen, Wilkinson, Shawcross, Abdoulaye Faye, Higginbotham, Lawrence, Diao, Whelan, Delap, Beattie, Fuller, Simonsen, Etherington, Amdy Faye, Camara, Sonko, Cresswell, Cort, Pugh, Tonge, Griffin, Olofinjana.
West Ham v Sunderland (Saturday, 3pm)
West Ham striker Carlton Cole has a groin injury and may be out for the rest of the season. Scott Parker is carrying a groin problem but may still play, while Radoslav Kovac (thigh) has also picked up a knock.
Central defenders Matthew Upson and James Collins are both fit for selection after missing the last two matches, Savio Nsereko has recovered from a minor knee injury, but Valon Behrami, Jack Collison (both knee) and Danny Gabbidon (back/stomach) are out.
West Ham (from): Green, Neill, Tomkins, Spector, Ilunga, Noble, Parker, Kovac, Boa Morte, López, Tristán, Payne, Di Michele, Dyer, Lastuvka, Sears, N'Gala, Stanislas, Upson, Collins, Savio.
Kieran Richardson returns from suspension for Sunderland's game against West Ham. But George McCartney is a doubt after sustaining a calf injury in Northern Ireland's win over Slovenia on Wednesday and Calum Davenport is ineligible because he is on loan from the Hammers.
Ricky Sbragia will give late fitness checks to Kenwyne Jones and Carlos Edwards, who did not get back from international duty in the USA until Friday.
Craig Gordon is pushing for a return after playing for Scotland in midweek and Nyron Nosworthy returns to the squad after coming through a reserve game on Thursday.
Sunderland (from): Fulop, Gordon, Bardsley, Ferdinand, Ben-Haim, Collins, Nosworthy, McCartney, McShane, Edwards, Malbranque, Whitehead, Leadbitter, Richardson, Reid, Murphy, Jones, Healy, Cisse.